School of Biology and Ecology Seminar
Dr. Steve Munger, The Jackson Laboratory
(Host: Han Tan)
“Harnessing Genetic Diversity to Discover Protein Regulatory Networks”
The Munger Lab explores natural genetic variation segregating in populations to discover how mutations that assert subtle individual effects can, in combination, disrupt gene regulatory networks and confer genetic susceptibility to developmental anomalies, adult disorder, and disease. The research integrates in vivo and in vitro experimental assays and computational methods with advanced mapping populations – an emerging multidisciplinary field called Systems Genetics – to identify causal genetic variants and network interactions that underlie phenotypic variability in 1) transcript abundance, protein expression, and organ function in adult tissues and 2) disease ecology and severity in a mouse model of Cornelia de Lange Syndrome. Munger has extensive training in developmental biology, complex trait genetics, genomics, and bioinformatics. He values collaborative science, and seeks to apply his computational expertise and the analytical methods he has developed to empower other researchers working with high throughput sequencing data from genetically diverse cohorts.
Seminars will be held on Fridays at 3:15 pm in 107 Norman Smith Hall, unless otherwise noted.
Light refreshments served at 3:00 p.m.